Antiemetic for canine and feline.
Unipramida Drops is an antiemetic and digestive of choice because metoclopramide has an antidopaminergic activity. It depresses the chemoreceptors area but also promotes the release and increases the sensitivity of visceral smooth muscle to acetylcholine. Central control mechanisms may also be involved in its action. The pharmacodynamic effects of Metoclopramide include increasing the tone of the lower esophageal sphincter, increasing the strength and frequency of gastric contractions, facilitating gastric emptying with better coordination of pyloric relaxation and duodenal motility and decreased transit time in the proximal small intestine.
Metoclopramide acts in the digestive tract and the CNS. In the upper digestive tract Metoclopramide increases the release of acetylcholine in neurons and cholinergic sensitivity to acetylcholine receptors. Many alterations in gastrointestinal activity are due to cholinergic stimulation disorder, which explains why the metoclopramide is most effective in diseases with reduced or altered motility.
Metoclopramide is a dopamine antagonist which is beneficial in the gastrointestinal tract in which dopamine inhibits motility. Metoclopramide crosses easily the blood brain barrier where dopamine antagonism produces an antiemetic effect in the chemoreceptor stimulation area.
Formula | Every 100 ml contains:
Metoclopramide hydrochloride …………………………. 500.0 mg
Excipients ……………………………………… 100.0 ml
Indications / Uses:
Antiemetic, nauseous, digestive states. esophageal reflux. Gastritis. chronic gastritis associated with delayed gastric emptying. Paralysis.
Administration and dosage:
Dogs and cats: 1 ml (20 drops) per 10 kg every 6 to 8 hours.
Contraindications / Precautions:
It is contraindicated in cases of intestinal obstruction or perforation, epilepsy and in animals treated with neuroleptics.
20 ml dropper bottle
Keep between 5 ° C and 35 ° C.
Keep away from direct sunlight, moisture and heat.
Keep out of the reach of children.