Triamcinolone acetonide is a highly potent synthetic glucorticoid and anti-inflammatory agent for parenteral administration in the treatment of bovine ketosis, arthritis, and dermatosis in other animal species.
Hampton triamcinolone is recommended for the treatment of bovine ketosis. In cats, dogs and horses it is recommended for:
a) symptomatic treatment of arthritis and related disorders, mainly traumatic arthritis and tenosynovitis.
b) in the management of dermatological disorders, and
c) in the treatment of allergic reactions.
FUNDAMENTALS FOR ITS USE:
Bovine Ketosis: Rapid remission of the signs and symptoms of Bovine Ketosis is achieved after intramuscular administration of TRIAMCINOLONE HAMPTON. Depending on the severity of ketosis, blood glucose is above normal values, dropping after injection to normal levels.
When ketosis has caused reduced milk production, it can be expected to increase 48 to 72 hours after TRIAMCINOLONE HAMPTON administration . The appetite and general appearance of the animal usually improve within 18 to 24 hours.
Triamcinolone acetonide is not excreted in milk, therefore, it is not necessary to discard milk obtained from treated animals.
Arthritis and related disorders: TRIAMCINOLONE HAMPTON injection provides rapid pain relief and reduces inflammation and swelling.
TRIAMCINOLONE HAMPTON can be applied intramuscularly, intraarticularly or intra-synovially depending on the nature of the lesion.
The response is usually characterized by improved mobility and decreased pain within 24 hours, followed by disappearance of the swelling.
The speed of return to the normal state depends on the degree of irreversibility of the pathological changes present. TRIAMCINOLONE HAMPTON will have no effect on the pathological changes of rheumatoid arthritis that has lasted for a long time.
Allergy and dermatological lesions: intramuscular or subcutaneous administration of TRIAMCINOLONE HAMPTON provides early and prolonged relief in the management of allergic symptoms, such as conjunctivitis or reactions to insect bites and in various dermatoses; inflammation, edema and itching are suppressed and the discomfort disappears within the first 24 hours. As itching is lessened or prevented, the lesions can heal more quickly. In many cases a single injection is enough to end the symptoms.
If necessary, the treatment can be repeated.
The intralesional administration of TRIAMCINOLONE HAMPTON is effective in the treatment of dermatological disorders in dogs and cats such as wet eczema, friction acanthosis and other dermatitis. Swelling and itching often goes away within 24-72 hours. A single intralesional injection is usually sufficient to achieve remission or elimination of the lesion, within a period of 1 to 2 weeks.
Its use is contraindicated in gastrointestinal ulcers, Cushing’s disease.
Do not use in viral infections, except in emergency therapy, do not use in animals with tuberculosis, chronic nephritis, Cushing’s syndrome and peptic ulcers.
It should be used with caution in animals with infections, kidney failure, corneal ulcers, hypertension, osteoporosis, diabetes mellitus, and congestive heart failure.
Its use is not recommended in pregnant animals.
After prolonged treatment, abrupt withdrawal can cause hypothalamic-pituitary-adrenal axis failure, therefore it is advisable to reduce the dose gradually.
Clinical and experimental data have shown that corticosteroids administered orally or parenterally to animals, can induce the first state of labor when administered during the last trimester of gestation, can precipitate preterm delivery followed by dystocia fetal death, placental retention and metritis.
Triamcinolone Hampton should not be used in the presence of any infection that cannot be controlled by concomitant antimicrobial therapy.
The anti-inflammatory action of corticosteroids can mask signs of an infection and treatment should be interrupted until a diagnosis is made. Overdose of some corticosteroids can result in sodium retention, fluid retention, potassium loss, and weight gain.
Inject with sterile disposable material, after asepsis on the surface to be inoculated.
DOSAGE AND ADMINISTRATION:
Intramuscular or subcutaneous. In bovine ketosis: the suggested dose is 0.4 to 1.7 ml (2.5 to 10 mg) giving a single intramuscular injection. The dose can be repeated after 48 hours, if necessary. The concomitant use of dextrose is recommended in order to accelerate the return of the blood sugar level to normal.
All cases of ketosis should be observed for an adequate period. Symptoms may recur in some animals 4 to 40 days after treatment. Imminent relapses can be evidenced by a decrease in appetite and a drop in milk production. Recurrent cases of bovine ketosis can be prevented by administering 0.4 to 1.7 ml (2.5 to 10 mg) of asteroid immediately after signs and symptoms of ketosis are observed.
Dogs and Cats: The suggested dose is a single injection of 0.016 to 0.033 ml / kg (0.1 to 0.2 mg / kg) of weight in arthritis or allergy and 0.033 ml / kg (0.2 mg / kg) of weight in dermatological disorders. Symptom remission, if not permanent, usually lasts 7 to 15 days. After this period, if symptoms recur, the dose may be repeated or oral corticosteroid therapy may be prescribed.
Horses: the suggested dose is 2.0 to 3.3 ml (12 to 20 mg).
In dogs and cats: intralesional injections will be circumscribed around the lesion at various sites to ensure adequate dose distribution. The injections will be spaced 0.5 cm to 2.5 cm depending on the size of the lesion. The distancing of the application reduces pain and / or pressure in the area capable of producing necrosis of the adjacent tissues.
The usual dose is 0.2 to 0.3 ml (1.2 to 1.8 mg) spaced around the injury. The dose injected at any site should not exceed 0.1 ml (0.6 mg) to minimize local tissue intolerance and atrophy, and be well done within the skin to prevent subsequent breakdown of the epidermis. The total dose should not exceed 1 ml (6 mg) when treating cats or dogs with multiple lesions. If necessary repeat the treatment.
It is preferable to use a tuberculin syringe with a small needle (23-25 gauge) to ensure the volume of the dose and facilitate administration.
Intraarticular and intrasynovial.
The dose for intra-articular and intrasynovial administration depends on the size of the joint to be treated and the severity of the symptoms. A single injection of 0.16 to 0.5 ml (1 to 3 mg) is recommended for cats and dogs 1 to 3 ml (6 to 18 mg) for horses. After three or four days the injections can be repeated depending on the severity of the symptoms and the clinical response. If the initial results are inadequate or too short-lived, the dose can be increased.
Before performing intra-articular injections, the area must be prepared aseptically.
In the treatments of tendinitis or tenosynovitis, the injection must be made in the tendon sheath.
Care must be taken to avoid injection into the tendon. After intra-articular administration, pain and other local symptoms may continue for a short time before effective relief is obtained, but increased joint discomfort is rare. A marked increase in pain accompanied by local swelling, fever, and malaise are indications of septic arthritis. If these complications occur and the diagnosis of sepsis is confirmed, antimicrobial therapy will be instituted immediately and continued until all evidence of infection has disappeared.
During treatment and 48 hours after its completion, the treated animals should not be destined for human consumption.
The milk produced during and 48 hours after treatment should not be used for human consumption.
Do not administer to equines that are intended for human food consumption.
In case of accidental injection by the operator, consult a doctor.