Antifungal for dogs, cats and rabbits
Griseofulvina 250 is an antibiotic which spectrum covers especially Microsporum, Trichophyton and Epidermophyton fungi.
It is absorbed mainly in the duodenum, followed by the jejunum and stomach. The degree of absorption depends on the size of the particles so Griseofulvina is micronized to double its absorption.
Griseofulvina has affinity with the skin so once absorbed, it goes to the blood where it is transported to the epidermis and deposited in basal cells. When these cells keratinize, they retain enough drugs to inhibit the dermatophyte growth .
The fungistatic action begins 4 days after starting treatment, 15 – 30 days after starting th etreatment the antibiotic appears on the entire surface of the epidermis. This estimate of time depends on the thickness and growth rate of the skin.
Formula | Each tablet contains:
Microcrystalline griseofulvin……………….. 250.0 mg
Excipentes q.s. …………………………………… 600.0 mg
Indications / Uses:
Cutaneous mycoses caused by fungi Trichophyton, Microsporum and Epidermophyton in both dogs and cats, laboratory animals and exotic.
Administration and dosage:
Canines: 20 – 40 – 60 mg per kg for 3 to 6 weeks.
Felines: 30 – 60 mg per kg per day for 4 weeks.
Guinea pigs: 30 – 40 mg per kg per day for 3 to 4 weeks.
Chinchillas: 30 – 40 mg per kg per day for 4 to 5 weeks.
In the dog and cat you may administer single doses of 150 mg/kg a week accompanying a high fat diet instead.
It is recommended to apply Griseofulvina topically (Griseofulvina Cream) as an adjunct in the treatment, avoiding the spread of spores.
Contraindications / Precautions:
Avoid use in pregnant animals and in animals under 60 days old.
Box with blister containing 20 tablets.
Keep between 5 ° C. and 35 degrees c.
Keep away from direct sunlight, moisture and heat.
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